Genetic Risk Factors for Cancer

The following are common risk factors for considering if there is an inherited genetic mutation in the family. If you find you have some of these risk factors, talk with your doctor to see if genetic counseling would be appropriate for you.

For Hereditary Breast and Ovarian Cancer:

  • Personal or family history of breast cancer before age 50 or ovarian cancer at any age
  • Patients with two or more primary diagnoses of breast and/or ovarian cancer
  • Male breast cancer
  • Relatives of patients with confirmed BRCA1 or BRCA2 mutation

For Hereditary Nonpolyposis Colorectal Cancer (HNPCC):

  • Patients with colorectal cancer (CRC) and a 1st degree relative with CRC or an HNPCC related cancer* diagnosed before age 50 OR Colorectal adenoma before age 40
  • Patients diagnosed with 2 HNPCC related cancers (endometrial, ovarian, gastric, kidney/urinary tract, biliary tract, brain, and/or small bowel cancer)
  • Relatives of patients with confirmed MLH1, MLH2 or MSH6 mutation

For Familial Adenomatous Polyposis (FAP) and Attenuated FAP (AFAP):

  • Patients affected with FAP (more than 100 colorectal adenomas)
  • Patients with suspected AFAP (more than 20 cumulative colorectal adenomas)
  • First degree relatives of patients with FAP or AFAP
  • Relatives of patients with confirmed APC mutation